Mechanistic Toxicology – The Molecular Basis of How Chemicals Disrupt Biological Targets – Second Edition

Inbunden bok. CRC Press, Taylor & Francis Group. 2 uppl. 2007. 399 sidor.

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Table of contents:
Introduction
Why Molecular Mechanisms?
Toxicokinetics and Toxicodynamics
Types of Toxic Responses
Adaptation to Cellular Stress
Toxic Responses
Disruption of Cytoprotective Mechanisms
Organ-Selective Toxicity
Biological Basis of Organ-Selective Toxicity
Selective Hepatotoxicity and Nephrotoxicity
Cellular Transport and Selective Accumulation of Potentially Toxic Xenobiotics
Transmembrane Transport of Xenobiotics
Cell-Specific Delivery of Xenobiotics to Intracellular Targets by Physiological Uptake Systems
Xenobiotic Export Pumps
Bioactivation of Xenobiotics to Reactive Metabolites
Biotransformation and Bioactivation/-Inactivation
Phase I (Functionalization) and Phase II (Conjugation) Reactions
Net Balance of Bioactivation/Bioinactivation for Risk Assessment
Mechanisms of Phototoxicity
Protective Mechanisms Against Reactive Metabolites: The Stress Response
Xenobiotic-Induced Oxidative Stress: Cell Injury, Signaling, and Gene Regulation
Reactive Oxygen Species (ROS) and Oxidoreductive Stress
Toxicological Consequences of Oxidative Stress
Interference with Antioxidant Defense Mechanisms
Intracellular Signaling and Gene Regulation by Oxidative Stress
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